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Contraindicated (1)pentobarbital will decrease the level or outcome of dienogest/estradiol valerate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Girls must not pick estradiol valerate/dienogest as their contraceptive while employing strong CYP3A4 inducers on account of potential reduce in contraceptive efficacy.pentoba

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